Join us on June 2 & 3, 2022 for the annual Having IMPACTT: Advancing Microbiome Research Symposium at the Malcolm Hotel in beautiful Canmore, Alberta, Canada

This exciting two-day microbiome symposium will highlight the latest microbiome research from across Canada and around the world.

Latest Publications

In this study, the authors identified microbial D-lactate, as a modulator of an intravascular immune firewall that protects against the spread of bacterial infections via the bloodstream.
Using an interdisciplinary approach, the authors identified three bacterial species that significantly enhanced the efficacy of immune checkpoint inhibitors in four mouse models of cancer! This promising study" identifies a novel microbial metabolite-immune pathway that may be exploited to develop microbial-based adjuvant therapies."
This review summarizes the milestone findings in the field of microbiota-intestinal T helper cell crosstalk with a focus on the role of specific commensal bacteria and their metabolites. The authors discuss mechanistic mouse studies and are linking these to human studies where possible. They also highlight recent advances in the field of microbial CD4 T cell epitope mimicry in autoimmune diseases and the role of microbially-induced CD4 T cells in cancer immune checkpoint blockade therapy.
Here we report that mice colonized with a combination of bacterial species with specific characteristics is required to inhibit IgE levels... inhibition of IgE induction can be mediated by specific microbes and their associated metabolic pathways and immunogenic properties.

The microbiome and immune memory formation

K. D McCoy, R. Burkhard, & M. B. Geuking . 05/2019

The microbiota plays an important role in regulating both the innate and adaptive immune systems. This review highlight the role of the microbiota in the induction of immune memory with a focus on both adaptive and innate memory as well as vaccine efficacy.

Read more discoveries by Dr. Geuking Here!

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